If you have a history of stomach problems, like stomach bleeding, TYLENOL® may be the right pain reliever for you. Learn more about your pain relief options. Tylenol (acetaminophen) and Motrin (ibuprofen) are pain relievers and fever reducers used for treating pain and fever associated with many conditions. Motrin is also used to treat inflammatory conditions such as arthritis. Aspirin vs Ibuprofen comparison. Ibuprofen and aspirin are over-the-counter NSAIDs used to relieve minor aches and pains and to reduce fever. But they are different in terms of their active ingredient, side effects, dosage and applications. It is sometimes not advisable to take ibuprofen. Active ingredient in Tylenol vs Advil. The active ingredient in Advil is ibuprofen, which is a non-steroidal anti-inflammatory drug. On the other hand, the active ingredient in Tylenol is acetaminophen (also known as paracetamol), an analgesic and an antipyretic agent. You may know acetaminophen as the brand-name drug Tylenol. A common brand name for ibuprofen is Advil. More brand names for these drugs are listed below. Advil (ibuprofen) is effective for treating fever, pain, and inflammation. Good for relieving pain due to common conditions like menstrual cramps, toothaches, backaches, and sports-related injuries. Acetaminophen relieves pain and also reduces fever. Brand names include Tylenol, Aceta, Apra and Mapap. Unlike NSAIDs, such as ibuprofen, it does not reduce inflammation. Acetaminophen vs. Ibuprofen: Which Works Better? Here, we pit acetaminophen (Tylenol®) against ibuprofen (Advil®, Motrin®). Find out which is better for headache, backache, fever, sore throat. Advil Sinus is a combination of ibuprofen and phenylephrine. Tylenol Sinus contains phenylephrine as well, but instead of ibuprofen, it uses acetaminophen. Difference between Tylenol, Advil and Aleve. For many people who have a headache or some other minor pain, Tylenol, Advil and Aleve are the brands commonly reached for.